it’s your bacteria that are eating allthat they are the ones who who actually benefit from it they utilize that toproduce then all the good chemicals suchas short chain fatty acids which will then improve diabetes make you reduceweight decrease inflammation morerestful sleepso welcome backand we’re going to continue this this talk and talking about nowthe bacteria what do they actually dothat makes us so healthy so it’s a veryvast subject and my of emphasis ofcourse is inflammation and height affects atherosclerosis uh in the humans
Understanding the immune system in the gut
Basically give you a schematic here ofuser gastrointestinal tract and you have your lymphoid tissue sitting out herethe lymph cells and these are all Tcells and B cells and other immune cells and there are other cells that actuallysit right very close to the to thelining and they send feelers out intothe gut andthese pillars tell them who’s therewhich kind of folks are there andwhether they’re friendly or not and they talk so they recognize thesebacteria that are in here and they send signals to the immune cells to say heyI’m a friend I’m a friend so thisimmunocyte says okay these are calledt-reg cells they say oh my job I’m aT-cell I’m a regulatory cell that meansI send a signal to all these other guysthat hey when this guy comes along heredo not fight him do not raise aninflammation on him don’t throw anybombs out at him okay so T-Rex why am Italking about t-rex cellsit appears that when you have a positivebacteria in the gut or the lack of
variety in the gut lack of variety of bugs you don’t have that spread of you know thousands and thousands of
different species that you’re supposed to have then you’re not going to get enough t-reg production or regulation of T cells so if your T Cell regulation is unchecked then when a bacteria does get Why you need a diverse gut flora in you’re going to get a profound
why what the baby starts eating is very important at a very young age because what’s happening here in the
gut and the variety of gut bacteria is going to tell your immune system slow down I’m taming the immune system so the problem we see today is too much inflammation too rapid fire too quick to draw the gun and fire and that’s what’s causing a lot of these diseases atherosclerosis inflammatory bowel disease autoimmune diseases even asthma and the like these are all overactive immune system a good immune system isnot overactive a good immune system isone that actually knows when it shouldgo into war and when it should not gointo war sothese dendritic cells and other T cellsthey have a vital role to play with thegut and the gut produces chemicals thataffect these these but not only thechemicals produced by the bacteriaaffect the local T cells and B cellsthey affect them systemically as well sothis is very important which kinds ofchemicals they produce and which
bacteria are producing The Beneficialones so we know that the ratio ofpermituities versus bacteroidase has tobe just right for the system to bebalanced and you can do tests for thatand people can do stool tests and say ohyour stools are mostly composed of thisbacteria or that bacteria and you canpredict that person’s weight and you caneven sometimes predict which diseasesthey have based on that it’s not ahundred percent but it’s about 70percent accurate at this time it canactually predict what your body massindex is going to be what conditionsyou’re likely to have but more important
Short Chain Fatty Acids and Probiotics
what the Genome of that Viral of that bacteria is making so it’s the products it’s called the postbiotics the
postbiotics the postbiotics are the chemicals that are made by the bacteria that are more important so they can be turned on genetically they can be turned on through their epige genetics just like how we have our epigenetics this can be turned on as well so these post biotics is what we should really bementioning so one of the key ones thatI’m very interested in is what is knownas short chain fatty acidsthese are produced by the verybenevolent bacteria in the gut what’s itto do with Cardiology wellthese hail the lining and we talkedabout early on that if your lining isleaky you have a problem well theseproduce the energy that’s required forthe endothelium itself under the liningof the gut itself so it makes the lininghealthier more energy for it andproduces more mucus
so when there’s more mucus lining thegutthere’s a better barrier between thebacteriaand your body you want lots of mucus forexample uh acomencia mucinophilia that’sa type of bacteria that’s very helpfulin humans it’s been shown to beextremely helpful white because it loveit produces certain chemicals includingshort chain fatty acids that increasethe mucous production and it actually even eats some of that mucus itself soit’s self-serving but with the excessmucus that’s produced there our gutlining is healthy when our gut lininggets eaten Away by the raw bacteriayou’re going to get leaky gut so we saidyou’re saying that when the wrongbacteria are there you have very littleackermans here you have a lot of badspecies over there or bad products the
mucus gets all chewed up gets eaten upyes then you’re going to get immuneactivation yes you’re going to get whattreatment this is you’re going to getinflammation it’s terrible terriblestuff’s going on hereand you can also change your epigeneticexpression of other molecules or othercells in the body as well through thosebad things that happen so the shortchain fatty acids improve the liningthey improve the mucous production butthey do other things too the butyratewhich is the main one that reduces systemicblood pressureit causes in the brain it can it canit’s been shown to increase bdnfum bdnf which is brain derivedneurotropic factor and it can heal theblood-brain barrier as well so the shortchain fatty acids are veryanti-inflammatoryand the more we make of thesethe better healthier the human being isgoing to be so can we identify how muchI’m making right now well this study isongoing unfortunately we don’t have thatso we can identify the species how dididentifying and keeping the goo
identifying and keeping the good bacteria alive
That happen well because we’ve measurethe genetics so the Human Genome Projectgave us the ability now to in a matterof hours you can sequence the DNA ofthousands of species of bacteria in yourin in your stool so it can be done so weidentifying the species now but we needto take it a step further we need toidentify what chemicals are beingproduced by those bacteria but we have apretty good idea already that one youneed a diverse microbiomewhat does that mean that means stop
killing themyou need a variety you need thousands ofspecies if you look at the stools of a auh let’s say for example in Africa who’seating mostly tubers and and Whole Foodshe’s got thousands and thousands ofspecies of bacteria and he still weighslike two pounds versus four ounces thatthe modern man is making I mean fourounces what’s this two pounds butfifty percent of the weight of his twois bacteria because he’s making he’s making all that bacteria population veryhealthy he’s got a lot of bacteria inhis gut so we know that the more diversethe gut bacteria the healthier the humanbeing you need to improve the diversityof your gut bacteria if you’re not goingto do that you’re gonna have multipleproblems in your healthit’ll go from the brain to the heart toatherosclosis to join problems to gutproblems name it you’re gonna get itmultiple sclerosis also even type 1diabetesall been associated with changes in thegut floor you need to have a diverse gutFlora why because the good take care
ofthe bad guys you know sometimes when youintroduce a good bacteriaand you get beneficial effects it’s notthe good bacteria’s direct effect it’sbecause that took care of something elsethat took care of something else andthen finally this species was able tothen increase so it’s very complicatedit’s very complicated because otherwiseyou’re going to say to me well Dr J whydon’t you just introduce the speciesgive me some acamenzia right now I want lots of accommendations I’m going to sipit all day long breakfast lunch anddinner you can’t do that you can’t dothat because it’s a long journey to goto the gutright so you may not even survive that
